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For example, Horner's syndrome causes anisocoria that results in small pupil size (pupil constriction). This is due to poor dilation of the involved pupil as a result of damage to sympathetic nerves. If the anisocoria increases in the darkroom, then the pupil with a small size is abnormal or involved. This is because anisocoria can be caused either due to pupil dilation or constriction of the pupil. The examination is done to check the presence of anisocoria and which pupil is abnormal or involved.

The examination involves checking the eyes in light and dark rooms. The diagnosis mainly involves a physical examination of the eyes and pupils. The diagnosis of anisocoria is done by eye specialist doctors known as ophthalmologists. Glaucoma that affects one eye can and cause excessive pressure buildup in the affected eye. Some types of headaches such as cluster headaches or migraine headaches.Ĭertain drugs or medicines, even some topical ophthalmic drugs, can cause anisocoria.

Seizures (seizures can cause temporary anisocoria, and the pupil size returns to normal once the seizure is over). Meningitis (swelling in the meninges or layers of the brain).Įncephalitis (swelling within the brain). Hemorrhage or bleeding inside skull (intracranial bleeding). Nervous system problems such as brain tumors and brain lesions. Injury and damage to the eye due to direct eye trauma.Ĭoncussion or mild traumatic brain injury.

The medical conditions that can cause anisocoria can include: However, in some cases, it can occur due to some severe medical conditions. In most cases, anisocoria is natural and is not a cause of concern.